|
KMID : 0357220100220030087
|
|
Journal of Korean Society Physical Therapy
2010 Volume.22 No. 3 p.87 ~ p.92
|
|
|
Electrical Stimulation Induces the Collagen Deposition and TGF-1 mRNA Expression in Skin Wound of Rat
|
|
Lee Jae-Hyoung
Park Chan-Eui
Park Rae-Joon
|
|
|
Abstract
|
|
|
Purpose: The purpose of this study was to investigate the effect of electrical stimulation (ES) on the wound closure rate, collagen deposition, and TGF-1 mRNA expression in skin wound of rat.
Methods: Twenty male Sprague-Dawley rats (222~271 g) were randomly divided into ES (n=10) and control group (n=10). The ES group received a cathodal stimulation with 50 V at 100 pps for 30 minutes for 7 days, while the control group was not given electrical stimulation. The wound closure rate, collagen density and TGF-1 mRNA ratio were measured.
Results: The mean wound closure rates in the ES and control groups were % and %, respectively (p<0.001). The collagen density in the ES and control groups were % and %, respectively (p<0.001). The TGF-1 mRNA ratio in the ES and control groups were and , respectively at 6 hours post-wound (p<0.01) and and , respectively, at 7 days post-wound (p<0.05).
Conclusions: ES accelerated the wound closure rate of skin incision wounds and was accompanied by an increase in collagen deposition in the regenerating dermis. In addition, ES increased TGF-1 mRNA expression during wound healing process. These findings suggest that ES may activate TGF-1 expression, and may increase synthesis activities of fibroblasts in regenerating skin wounds in rats.
|
|
|
KEYWORD
|
|
|
Electrical stimulation, Wound healing, Collagen density, TGF-1 mRNA, Rat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|